Restricted Research - Award List, Note/Discussion Page

Fiscal Year: 2018

1336  The University of Texas at Arlington  (74841)

Principal Investigator: Michael Nelson

Total Amount of Contract, Award, or Gift (Annual before 2011): $ 441,020

Exceeds $250,000 (Is it flagged?): Yes

Start and End Dates: 1/5/18 - 12/31/20

Restricted Research: YES

Academic Discipline: Department of Kinesiology

Department, Center, School, or Institute: College of Nursing and Health Innovation

Title of Contract, Award, or Gift: Defining specific mechanisms limiting oxygen delivery and utilization in heart failure with preserved ejection fraction: Novel insight from Near-Infrared Diffuse Correlation Spectroscopy

Name of Granting or Contracting Agency/Entity: National Institutes of Health (NIH)

Program Title: N/A
CFDA Linked: Heart and Vascular Diseases Research


Exercise intolerance is the hallmark symptom in patients with heart failure with preserved ejection fraction. As a consequence, activities of daily living require near maximal effort, resulting in further deconditioning and reduced quality of life.  While the exact mechanism for the exercise intolerance remains unclear, emerging evidence from our group and others, suggests that peripheral, ‘non-cardiac’ factors contribute significantly. However, no study to date has simultaneously measured skeletal muscle blood flow and oxidative metabolism in a single subject; making it difficult to assign causality or priority. Near-infrared diffuse correlation spectroscopy (DCS) has the potential to address these specific limitations, by simultaneously assessing skeletal muscle microvascular perfusion and oxygenation, as well as mitochondrial function. To test this hypothesis, we will construct and validate a broadband-NIRS/DCS hybrid system to quantify skeletal muscle perfusion and metabolic function in vivo. Once established, we will extend this novel technology to patients with HFpEF, in order to define specific mechanisms contributing to impaired peripheral oxygen utilization. Together, these studies will not only establish one of the most comprehensive imaging tools for assessing peripheral oxygen delivery and utilization, but will also provide new mechanistic insight into peripheral limitations to exercise in HFpEF.

Discussion: No discussion notes


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