Restricted Research - Award List, Note/Discussion Page

Fiscal Year: 2018

1327  The University of Texas at Arlington  (74832)

Principal Investigator: Hanli Liu

Total Amount of Contract, Award, or Gift (Annual before 2011): $ 2,852,229

Exceeds $250,000 (Is it flagged?): Yes

Start and End Dates: 8/1/17 - 7/31/21

Restricted Research: YES

Academic Discipline: Department of Bioengineering

Department, Center, School, or Institute: College of Engineering

Title of Contract, Award, or Gift: Novel Neuromodulation by Transcranial Infrared Brain Stimulation with Imaging

Name of Granting or Contracting Agency/Entity: National Institutes of Health (NIH)

Program Title: N/A
CFDA Linked: Mental Health Research Grants


The overall purpose of this project is to develop transcranial infrared brain stimulation (tIBS) as a new tool for non-invasive neuromodulation of the human brain. In recent years, we have consistently demonstrated that transcranial photobiomodulation with infrared lasers at 1064 nm can non-invasively induce cognitive-enhancing and brain-stimulatory effects in humans when the light is delivered at the prefrontal cortex. The mechanism of tIBS is fundamentally different from those of existing electrical or magnetic stimulations; tIBS is rather an optical method that putatively causes photo-oxidation of cytochrome c oxidase (CCO), the respiratory enzyme in mitochondria that catalyzes the metabolic use of oxygen. Since cerebral function is critically dependent on oxygen metabolism, TILS has strong potential to become a novel non-invasive form of photoneuromodulation for cognitive enhancement. The central hypothesis guiding this proposal is that tIBS can be developed, tested, and mechanistically interpreted for enhancing neurocognitive functions in humans with high spatial resolution. Accordingly, we have formed a strong, collaborative, and multidisciplinary team with excellent track records in the relevant disciplines to prove our hypothesis by accomplishing three specific aims. The study will involve non-invasive controlled studies of healthy participants in three sites of the University of Texas (Arlington, Austin, and Southwestern at Dallas). Aim 1: To test and demonstrate that TILS produces a new, non-invasive neuromodulation of human prefrontal cognition. Aim 2: To demonstrate the metabolic and hemodynamic mechanism of TILS by quantifying TILS-induced changes in redox state of mitochondrial CCO, and changes in HbO, HbT, & HbD in the human prefrontal cortex. Aim 3: To quantify TILS-induced neurophysiological effects in functional cortical networks and the coupling between electrophysiological and hemodynamic responses in the human brain in vivo.

Discussion: No discussion notes


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