Restricted Research - Award List, Note/Discussion Page

Fiscal Year: 2018

1305  The University of Texas Rio Grande Valley  (74810)

Principal Investigator: Sarah Reyna

Total Amount of Contract, Award, or Gift (Annual before 2011): $ 435,900

Exceeds $250,000 (Is it flagged?): Yes

Start and End Dates: 5/1/18 - 3/31/21

Restricted Research: YES

Academic Discipline: Biomedical Sciences

Department, Center, School, or Institute: School of Medicine

Title of Contract, Award, or Gift: Macrophage ERK Signaling and Its Application in Modulating Skeletal Muscle Insulin Resistance

Name of Granting or Contracting Agency/Entity: U.S. Department of Health & Human Services

Program Title: N/A
CFDA Linked: Biomedical Research and Research Training


The purpose of this project is to determine how specific proteins in macrophages may be involved in causing skeletal muscle inflammation and insulin resistance. To characterize the role of ERK1 and ERK2 in regulating TLR4 endocytosis and signaling. Using siRNA, ERK1 and ERK2 isoforms will be knocked down in bone marrow derived macrophages to determine the molecular mechanisms regulating TLR4 endocytosis. To assess the contributions of inhibiting ERK signaling in macrophages to the protection against insulin resistance, and to the regulation of skeletal muscle macrophage infiltration. Insulin clamp studies will be performed to examine whether ERK1 and ERK2 deficiencies in macrophages result in improved insulin sensitivity and protection against high fat diet-induced skeletal muscle inflammation and insulin resistance in a mouse model. The proposed studies in characterizing the phenotype of macrophage ERK1 and ERK2 will contribute to the unraveling and understanding of the specific functions of ERK1 and ERK2 isoforms.

Discussion: No discussion notes


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