Restricted Research - Award List, Note/Discussion Page

Fiscal Year: 2018

1298  The University of Texas Rio Grande Valley  (74803)

Principal Investigator: Joanne Curran

Total Amount of Contract, Award, or Gift (Annual before 2011): $ 2,359,705

Exceeds $250,000 (Is it flagged?): Yes

Start and End Dates: 1/15/18 - 12/31/21

Restricted Research: YES

Academic Discipline: South Texas Diabetes & Obesity Institute

Department, Center, School, or Institute: School of Medicine

Title of Contract, Award, or Gift: Genetic Determinants of Lipidomic Variation and Their Role in CVD Risk

Name of Granting or Contracting Agency/Entity: U.S. Department of Health & Human Services

Program Title: N/A
CFDA Linked: Heart and Vascular Diseases Research


This project is aimed to identify novel genes underlying the relationship between human lipid variation and CVD using a mixed longitudinal design in extended pedigrees with available whole genome sequence data. Such an approach may lead us to the identification of potential drug targets relevant for lipid modifying therapy. The project will exploit whole genome sequence (WGS) information using a mixed longitudinal design in powerful extended pedigrees of Mexican American individuals in combination with comprehensive measures of the human lipidome, to identify novel genes and functional variants influencing lipid variation and risk of CVD development. This project will generate novel lipid endophenotypes that may represent better predictors of disease risk. The combination of these precise biological phenotypes and WGS gives us an unprecedented opportunity to identify novel genes and functional variants influencing human lipid variation and risk of CVD. To

Discussion: No discussion notes


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