Restricted Research - Award List, Note/Discussion Page

Fiscal Year: 2018

881  The University of Texas at Dallas  (74386)

Principal Investigator: Theodore J Price

Total Amount of Contract, Award, or Gift (Annual before 2011): $ 2,449,596

Exceeds $250,000 (Is it flagged?): Yes

Start and End Dates: 8/1/17 - 7/31/18

Restricted Research: YES

Academic Discipline: Behavioral And Brain Sciences

Department, Center, School, or Institute: BBS

Title of Contract, Award, or Gift: Protease Activated Receptor Type 2 Targeting for Migraine Pain

Name of Granting or Contracting Agency/Entity: Natl Institutes of Health

Program Title: N/A
CFDA Linked: Extramural Research Programs in the Neurosciences and Neurological Disorders


The central hypothesis of this multi-PI research program is that PAR2 expression in nociceptors that project to the meninges plays a key role in the pathogenesis of migraine pain by linking meningeal protease release to sensitization of the trigeminal nociceptive system. The primary objectives of this proposal are to develop next generation PAR2 antagonists, to use these tools to validate PAR2 as a migraine pain target and to use mouse genetics to identify the specific role of PAR2 expression in meningeal projecting nociceptors to migraine pain.

Discussion: No discussion notes


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