Restricted Research - Award List, Note/Discussion Page

Fiscal Year: 2018

594  Texas Tech University  (73807)

Principal Investigator: Michael P. Latham

Total Amount of Contract, Award, or Gift (Annual before 2011): $ 850,876

Exceeds $250,000 (Is it flagged?): Yes

Start and End Dates: 3/1/18 - 2/28/21

Restricted Research: YES

Academic Discipline: Chemistry

Department, Center, School, or Institute: Chemistry

Title of Contract, Award, or Gift: CPRIT Structural and Functional Characterization of the DNA Double Strand Break Processing Complex of Mre-11-Rad50

Name of Granting or Contracting Agency/Entity: Cancer Prevention and Research Institute of Texas (CPRIT)

Program Title: N/A


1.1.1: The purpose of this research award is to determine structural models of the MRN complex bound to mimics of damaged DNA to allow for a better description of the motions that occur between various functional states. This work also seeks to characterize known MRN mutations that have likely lead to genomic instability and cancer in patients as well as a novel mutation that renders some cancer cells sensitive to existing chemotherapies. Success of this proposed work would present a better understanding of the working states of a critical DNA damage repair complex, increased knowledge for the initial steps in DNA DSB repair, and pave the way for future studies aimed at the discovery of novel MRN inhibitors.

Discussion: No discussion notes


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