Restricted Research - Award List, Note/Discussion Page

Fiscal Year: 2018

480  Texas Tech University  (73693)

Principal Investigator: John C. D'Auria

Total Amount of Contract, Award, or Gift (Annual before 2011): $ 332,348

Exceeds $250,000 (Is it flagged?): Yes

Start and End Dates: 8/15/17 - 7/31/20

Restricted Research: YES

Academic Discipline: Chemistry

Department, Center, School, or Institute: Chemistry

Title of Contract, Award, or Gift: Collaborative Research A System Approach Toward Understanding the Diversification of Tropane and Granatane Alkaloid Biosynthesis

Name of Granting or Contracting Agency/Entity: National Science Foundation

Program Title: N/A
CFDA Linked: Biological Sciences


1.1.1: This collaborative research award supports utilizing a top down approach of combined transcriptomics and metabolomics coupled with comparative functional, biochemical and structural biology based approaches to elucidate the pathways that underlie the biosynthesis of the pharmaceutically important tropane and granatane alkaloids. Gene discovery will occur in three evolutionarily distinct and important crop families: Brassicaceae, Lythraceae and Erythroxylaceae and the resulting data will be compared to an established tropane alkaloid pathway in the Solanaceae. This comparative approach will be used to test the hypothesis that novel biocatalytic activities within the tropane biosynthetic pathways of distinct species are the source of the independent emergence of the tropane alkaloid system within different plant lineages.

Discussion: No discussion notes


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