Restricted Research - Award List, Note/Discussion Page

Fiscal Year: 2014

1273  University of Houston  (22833)

Principal Investigator: TAM,VINCENT

Total Amount of Contract, Award, or Gift (Annual before 2011): $ 545,894

Exceeds $250,000 (Is it flagged?): Yes

Start and End Dates: 2/1/14 <> 1/31/18

Restricted Research: YES


Department, Center, School, or Institute: PHARMACY PH

Title of Contract, Award, or Gift: Therapeutic Beta-Lactam Monitoring for Stratified Treatment of hospital-acquired pneumonia, improved dose-dependent efficacy, decreased treatment duration, and prevention of emergence of resistance

Name of Granting or Contracting Agency/Entity: Commission of the European Community

Program Title: none


We will perform experiments using an established in vitro infection model to demonstrate the emergence of drug resistance can be suppressed by optimal PK/PD profiles of beta-lactams. The established target drug exposures to suppress emergence of drug resistance will be adopted in the dosing algorithm of the subsequent clinical study.

Discussion: No discussion notes


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