Restricted Research - Award List, Note/Discussion Page

Fiscal Year: 2013

1707  University of Houston  (21185)

Principal Investigator: ZUFALL,REBECCA

Total Amount of Contract, Award, or Gift (Annual before 2011): $ 296,226

Exceeds $250,000 (Is it flagged?): Yes

Start and End Dates: 5/1/13 <> 4/30/14

Restricted Research: YES

Academic Discipline: BIOLOGY & BIOCHEMISTRY

Department, Center, School, or Institute: NSM

Title of Contract, Award, or Gift: Mutation accumulation in the ciliate Tetrahymena thermophila

Name of Granting or Contracting Agency/Entity: National Institute of General Medical Sciences

Program Title: none
CFDA Linked: Biomedical Research and Research Training


1R01GM101352-01A1 - We propose to use T. thermophila in a mutation accumulation experiment. Follow--?up experiments with the lines that we generate using a range of complementary genetic and genomic tools, combined with powerful computational and statistical analyses will allow us to estimate germline mutational parameters with high robustness and accuracy, including: the overall mutation rate; the rate and effect sizes of mutations deleterious to fitness; their dominance and epistatic relationships; the rate of recessive lethal mutations; and the spectrum of mutations at the molecular level. We will also be able to compare the rates, distributions of effects and molecular spectra of mutations occurring in the somatic and germline genomes.

Discussion: No discussion notes


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