Fiscal Year: 2013
1700 University of Houston (21178)
Principal Investigator: HARWERTH,RONALD S.
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 360,000
Exceeds $250,000 (Is it flagged?): Yes
Start and End Dates: 9/30/12 <> 8/31/13
Restricted Research: YES
Academic Discipline: OPT VISION SCIENCES
Department, Center, School, or Institute: OPTOMETRY
Title of Contract, Award, or Gift: Behavioral Measures of Vision
Name of Granting or Contracting Agency/Entity:
National Eye Institute
CFDA Link: HHS
CFDA Linked: Vision Research
2R01EY001139-35A1 - The goal of the proposed research is to gain a better understanding of the relationships between clinical measures of neural and visual losses from glaucoma, especially the psycho-physiological links between structure and function. The principal experiments involve behavioral studies of visual function (standard automated perimetry) and high resolution imaging of retinal structure (optical coherence tomography) over the time course of experimental glaucoma in macaque monkeys. The data from the investigations of experimental glaucoma will be used to 1) develop a quantitative model relating the loss of retinal neurons in a specific area of the retina to the number of axons entering the optic nerve from the same retinal area and 2) To investigate the temporal relationships of the clinical signs of glaucomatous neuropathy that involve losses in visual sensitivity, increased cupping of the optic nerve head, and thinning of the neuronal layers of the outer retina. In the final phase, the relationships that were derived from experimental glaucoma in monkeys will be applied to assess the severity, or stage, of glaucoma in human patients.
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